Jesus is now expected to deputise up front over the coming games starting against Donetsk on Tuesday night where City need just a point to qualify from Group C and book their place in the knockout stages of the Champions League.
Jose Mourinho wasted little time in making his mark at Tottenham after he was brought in to replace Mauricio Pochettino, guiding the north London club to a 3-2 win over sorry rivals West Ham. "My teams, always we try but I accept that the others can better".
Manchester City, meanwhile, bounced back from their damaging 3-1 defeat to Liverpool before the worldwide break with an entertaining 2-1 victory against Chelsea - a result which saw them leapfrog Frank Lampard's side into third.
Jesus has been restricted to just four Premier League starts this term, but is likely to be drafted in for Aguero while he recovers from his tendon issue.
Roberto Firmino had the final say, though, prodding home after a corner had caused chaos in the Palace penalty area.
Taking last season into account, the Reds are unbeaten in 30 Premier League matches stretching back to a defeat against Manchester City at Etihad Stadium at the start of January. It's not the first time Manchester City in 100 years of history lose the league. We wrote how Joe Gomez was living in Guardiola's head after clubs got their players back from the global break and the City boss can't escape the Reds.
Chris Wilder's newly-promoted side have impressed already this season and went into the game ahead of Manchester United in the table.
N'Golo Kante gave Chelsea a 21st-minute lead but, remarkably, Lampard's side did not manage another shot on target for the remainder of the match. The highlight from the Etihad Stadium saw Manchester City come from behind to beat Chelsea 2-1.
Aguero has been in sensational form for City this season, scoring 13 goals in 16 games in all competitions. A first game in charge for Jose Mourinho ends in a win in West Ham 2-3 Tottenham in a Premier League highlight. Williams, Greenwood and Rashford scored for Man United vs Sheffield United in the Premier League.
And Klopp has admitted that he has been thrilled by the way his side have started the new Premier League campaign.