Around 60 firefighters are tackling a blaze at the Koko club in Camden, north London.
London Fire Brigade said that 22 people called the emergency line to notify officials of the fire.
The brigade said 30% of the roof was alight and it was "working hard" to save the rest of the building.
Firefighters have tackled a blaze at a historic music venue which has hosted acts such as Madonna, Ed Sheeran and Prince. No one was reported as being hurt in the fire.
Camden's iconic nightclub, Koko, was on fire tonight as firefighters struggled to save the place. It was set to reopen this spring.
It is now closed and undergoing refurbishment, and was set to reopen in spring.
Disappointing when looking at the Camden Palace / Koko in flames this evening, a building which holds so many memories and which means a lot to us in Camden. "Incredible how quickly @LondonFire got under control, we owe them so much for their swift and courageous response".
A fire broke out at the renowned Koko in Camden at approximately 9pm this evening (January 6), sending huge plumes of black smoke billowing into the air.
At 8:56 p.m., the London fire department sent fire engines and 60 firefighters to visit the scene.
Reports of a cause for the fire are not being reported at this time.