Bill O'Brien's team took care of that very quickly when Deshaun Watson found several holes in Kansas City's coverage and hit Kenny Stills for a 54-yard touchdown with 12:07 left in the first quarter.
After early betting following Sunday's divisional playoff games, the Chiefs are 7.5-point favorites over the Titans with the Over/Under at 52 and potentially climbing while the 49ers are 7-point favorites over the Packers with a lower Over/Under of 45. The Chiefs also have reigning NFL MVP Patrick Mahomes on their side, and their offense averaged 379.2 yards per game in the regular season. The Titans upset the No. 1 seeded AFC squad, the Baltimore Ravens.
The Chiefs punched their ticket into Sunday's showdown at Arrowhead Stadium with a 51-31 win over the Texans on Sunday.
The 49ers dispatched the Minnesota Vikings easily in the Divisional Round and will host Green Bay, a team San Francisco beat handily back in Week 12. He said the thought during the week was the team that would run the ball 30 times would likely win the game.
The Titans rallied in the fourth quarter to beat the Chiefs 35-32 in the teams' wild Week 10 game in Nashville, the last time Kansas City has lost a game.
Henry has carried the Titans on his back in the post-season and their star pulled off the trick play of the playoffs so far by connecting on a three-yard jump pass with Davis for a third-quarter touchdown. The win over Houston on Sunday was the Chiefs' seventh consecutive victory.
Seahawks quarterback Russell Wilson threw for 277 yards and rushed for 64, while Marshawn Lynch scored two touchdowns.
"We've already played them and we know they're a tough team", Mahomes said. "That's the biggest thing you saw here today was we've just got to find a way no matter what". Although he completed 21 of 29 passes, he totaled just 172 yards with a touchdown and interception in a 27-10 loss.
The model ranked in the Top 10 on NFLPickWatch the past three years on straight-up National Football League picks and beat more than 96 percent of CBS Sports office pool players last season.
The number 6 seed Titans as an underdog is not really a surprise.
Mahomes threw a five-yard touchdown pass to cap off the three-play, 33-yard drive.
Ryan Tannehill took over as the Titans starting quarterback when he replaced Marcus Mariota during a 16-0 loss to Denver. He has rushed for 180 or more yards in each of the last three games, including two playoff contests.